C1q and TNF related 1Genealiases: CTRP1 · GIP · ZSIG37
Q-omics provides the consensus-scored C1QTNF1 profile across patient tissues and cancer cell-line models. C1QTNF1 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, C1QTNF1 is differentially expressed in 11, with the highest sampling consensus in COAD. Additionally, C1QTNF1 RNA expression shows 16,502 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight KIRC, COAD, and LSCC as cancer lineages where C1QTNF1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for C1QTNF1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes C1QTNF1 survival associations across molecular data types. C1QTNF1 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (8) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible C1QTNF1 RNA expression–survival associations across cancer types. High C1QTNF1 expression shows unfavorable associations in KIRC, LGG, COAD, STAD and CESC, but favorable associations in PAAD. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for C1QTNF1 RNA expression.
This table summarizes C1QTNF1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for C1QTNF1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. C1QTNF1 shows lower tumor expression in KICH, LIHC and UCEC and higher tumor expression in COAD, HNSC and KIRC. The COAD box plot shows higher C1QTNF1 RNA expression in tumor versus normal tissue (log2 FC = +1.562, t-test p < 0.001).
This table shows molecular features associated with C1QTNF1 in patient tissues and cancer cell lines. In patient samples, C1QTNF1 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, C1QTNF1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BONE, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and SOFT_TISSUE.
