Q-omics provides the consensus-scored BLOC1S5-TXNDC5 profile across patient tissues and cancer cell-line models. BLOC1S5-TXNDC5 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, BLOC1S5-TXNDC5 is differentially expressed in 11, with the highest sampling consensus in KICH. Additionally, BLOC1S5-TXNDC5 RNA expression shows 14,836 significant gene co-expression associations, with the highest sampling consensus in KIRP. Together, these results highlight UCEC, KICH, and KIRP as cancer lineages where BLOC1S5-TXNDC5 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for BLOC1S5-TXNDC5 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes BLOC1S5-TXNDC5 survival associations across molecular data types. BLOC1S5-TXNDC5 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible BLOC1S5-TXNDC5 RNA expression–survival associations across cancer types. High BLOC1S5-TXNDC5 expression shows unfavorable associations in UCEC and ACC, but favorable associations in SKCM, THCA, CHOL and KIRC. The UCEC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify UCEC as the clearest survival context for BLOC1S5-TXNDC5 RNA expression.
This table summarizes BLOC1S5-TXNDC5 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in KICH for RNA.
This table ranks reproducible tumor–normal expression differences for BLOC1S5-TXNDC5. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. BLOC1S5-TXNDC5 shows lower tumor expression in KICH, COAD, KIRC, BRCA, LUSC and LUAD. The KICH box plot shows higher BLOC1S5-TXNDC5 RNA expression in normal versus tumor tissue (log2 FC = −1.462, t-test p < 0.001).
This table shows molecular features associated with BLOC1S5-TXNDC5 in patient tissues and cancer cell lines. In patient samples, BLOC1S5-TXNDC5 shows the broadest associations at the RNA and protein expression levels, with KIRP recurring as the lineage with the largest associated feature set. In cancer cell lines, BLOC1S5-TXNDC5 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BREAST, while CRISPR and shRNA rows add functional-dependency signals in BONE and LUNG_SCLC.
