BLOC1S5-TXNDC5

Across TCGA pan-cancer cohorts, BLOC1S5-TXNDC5 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of BLOC1S5-TXNDC5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where BLOC1S5-TXNDC5 RNA is repressed in tumor relative to normal tissue. In most cancer types BLOC1S5-TXNDC5 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and KIRC are the cancer types where BLOC1S5-TXNDC5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BLOC1S5-TXNDC5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.462	<.001	11	view →
COAD	All	IV	−0.300	<.001	11	view →
KIRC	Male	IV	−1.108	<.001	10	view →
BRCA	All	II,III,IV	−0.488	<.001	8	view →
LUSC	Female	All	−0.765	<.001	7	view →
LUAD	Female	III,IV	−1.142	<.001	6	view →
KIRP	Male	All	−0.758	<.001	5	view →
UCEC	All	III,IV	−0.595	.006	4	view →
CHOL	All	All	+0.666	.015	2	view →
READ	Female	All	−0.306	.004	2	view →
LIHC	All	III,IV	−0.102	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

BLOC1S5-TXNDC5–KICH

Open the KICH breakdown →