BLOC1S5-TXNDC5

Across TCGA pan-cancer cohorts, BLOC1S5-TXNDC5 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated BLOC1S5-TXNDC5 data layer compared with 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher BLOC1S5-TXNDC5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated BLOC1S5-TXNDC5 expression acts as an unfavorable survival marker, although some lineages such as SKCM and THCA show a favorable association.

UCEC, ACC, and SKCM are the cancer types where BLOC1S5-TXNDC5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	0.437	0.681	.002	64	view →
ACC	OS	Quartile	All	0.231	0.894	.003	48	view →
SKCM	OS	Tertile	All	0.432	0.245	<.001	41	view →
THCA	DFS	Tertile	IV	1.000	0.711	.002	31	view →
CHOL	DFS	Tertile	All	0.797	0.119	.004	24	view →
KIRC	DFS	Quartile	III,IV	0.526	0.223	.005	20	view →
MESO	OS	Quartile	II,III,IV	0.282	0.640	.005	18	view →
LGG	DFS	Tertile	All	0.784	0.668	.005	18	view →
KIRP	DFS	Quartile	IV	0.028	0.687	.038	18	view →
LUSC	DFS	Tertile	II,III,IV	0.245	0.734	<.001	16	view →
UVM	OS	Tertile	III,IV	0.272	1.000	.027	15	view →
PAAD	DFS	Quartile	All	0.682	0.434	.036	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

BLOC1S5-TXNDC5–UCEC (DFS)

Open the UCEC breakdown →