BLOC1S5-TXNDC5

Across TCGA pan-cancer cohorts, BLOC1S5-TXNDC5 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BLOC1S5-TXNDC5 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher BLOC1S5-TXNDC5 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated BLOC1S5-TXNDC5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

KIRP, COAD, and UCEC are the cancer types where BLOC1S5-TXNDC5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.310	0.871	<.001	14	view →
COAD	OS	Median	III,IV	0.252	0.696	.017	12	view →
UCEC	DFS	Median	All	0.943	0.616	.013	6	view →
SKCM	DFS	Median	II,III,IV	0.911	0.559	.026	4	view →
LUAD	DFS	Median	All	1.000	0.657	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

BLOC1S5-TXNDC5–KIRP (DFS)

Open the KIRP breakdown →