BLOC1S5-TXNDC5

Across TCGA patient cohorts, BLOC1S5-TXNDC5 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BLOC1S5-TXNDC5-associated genes across cancer lineages are EGFR, FoxM1, and GAPDH. Each is linked with BLOC1S5-TXNDC5 in more than 2 cancer types. Because this analysis shows association rather than direction, both BLOC1S5-TXNDC5-to-partner and partner-to-BLOC1S5-TXNDC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by BLOC1S5-TXNDC5-low versus BLOC1S5-TXNDC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLOC1S5-TXNDC5→partner) and Y-score (partner→BLOC1S5-TXNDC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.134	-1.415	.011	.043	3	2
UCEC	FoxM1 →	+0.250	+2.263	.003	<.001	3	2
UCEC	GAPDH →	+0.531	+2.415	.002	.002	3	2
SKCM	ACC1 →	+0.433	+2.820	.014	.035	3	2
UCEC	P-Cadherin →	-0.165	-2.999	<.001	<.001	3	2
UCEC	PKC-delta_pS664 →	-0.121	-3.087	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

EGFR by BLOC1S5-TXNDC5 expression — UCEC

Explore this box plot interactively →