BLOC1S5-TXNDC5

Across TCGA cell cohorts, BLOC1S5-TXNDC5 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible BLOC1S5-TXNDC5-associated genes across cancer lineages are IL3, PRAMEF10, and PRAMEF17. Each is linked with BLOC1S5-TXNDC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both BLOC1S5-TXNDC5-to-partner and partner-to-BLOC1S5-TXNDC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL3 grouped by BLOC1S5-TXNDC5-low versus BLOC1S5-TXNDC5-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLOC1S5-TXNDC5→partner) and Y-score (partner→BLOC1S5-TXNDC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IL3 →	+0.055	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF10 →	+1.180	+5.643	<.001	.002	3	1
LUNG_SCLC	PRAMEF17 →	+0.013	+5.643	<.001	.002	3	1
LUNG_SCLC	SPINK8 →	+0.513	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

IL3 by BLOC1S5-TXNDC5 expression — LUNG_SCLC

Explore this box plot interactively →