BLOC1S5-TXNDC5

Across TCGA patient cohorts, BLOC1S5-TXNDC5 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,147 significant associations in total. COAD shows the largest number of these associations.

The most reproducible BLOC1S5-TXNDC5-associated GO terms across cancer lineages are Mineralocorticoid biosynthetic process, Regulation of endothelial cell differentiation, and Regulation of aldosterone metabolic process. Each is linked with BLOC1S5-TXNDC5 in more than 24 cancer types. Because this analysis shows association rather than direction, both BLOC1S5-TXNDC5-to-partner and partner-to-BLOC1S5-TXNDC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mineralocorticoid biosynthetic process grouped by BLOC1S5-TXNDC5-low versus BLOC1S5-TXNDC5-high in ACC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BLOC1S5-TXNDC5→partner) and Y-score (partner→BLOC1S5-TXNDC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	Mineralocorticoid biosynthetic process →	+0.078	+0.654	<.001	<.001	3	25
KIRC	Regulation of endothelial cell differentiation →	+0.048	+0.251	<.001	<.001	3	24
UCS	Regulation of aldosterone metabolic process →	+0.100	+0.592	<.001	.001	2	25
ESCA	Positive regulation of lipopolysaccharide-mediated signaling pathway →	+0.074	+0.259	<.001	<.001	3	23
KIRP	Type B pancreatic cell development →	+0.063	+0.627	<.001	<.001	3	23
ACC	Mineralocorticoid metabolic process →	+0.101	+0.966	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,147 associations by consensus.

Mineralocorticoid biosynthetic process by BLOC1S5-TXNDC5 expression — ACC

Explore this box plot interactively →