ankyrin and armadillo repeat containingGenealiases: []
Q-omics provides the consensus-scored ANKAR profile across patient tissues and cancer cell-line models. ANKAR expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, ANKAR is differentially expressed in 9, with the highest sampling consensus in KIRC. Additionally, ANKAR RNA expression shows 21,525 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight ACC, KIRC, and UVM as cancer lineages where ANKAR shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ANKAR — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ANKAR survival associations across molecular data types. ANKAR RNA expression shows survival associations in the most cancer types (23), followed by mutation status (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ANKAR RNA expression–survival associations across cancer types. High ANKAR expression shows unfavorable associations in ACC, KIRP, LIHC, LGG and COAD, but favorable associations in BRCA. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for ANKAR RNA expression.
This table summarizes ANKAR tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for ANKAR. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ANKAR shows lower tumor expression in LUSC, BRCA, UCEC and KICH and higher tumor expression in KIRC and LIHC. The KIRC box plot shows higher ANKAR RNA expression in tumor versus normal tissue (log2 FC = +0.474, t-test p < 0.001).
This table shows molecular features associated with ANKAR in patient tissues and cancer cell lines. In patient samples, ANKAR shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, ANKAR RNA and mutation anchors are most strongly linked to RNA-expression features, especially in STOMACH, while CRISPR and shRNA rows add functional-dependency signals in BREAST and UPPER_AERODIGESTIVE_TRACT.
