ANKAR

Across TCGA patient cohorts, ANKAR mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKAR-associated genes across cancer lineages are p62 Lck ligand, Notch1, and PCNA. Each is linked with ANKAR in more than 3 cancer types. Because this analysis shows association rather than direction, both ANKAR-to-partner and partner-to-ANKAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ANKAR-low versus ANKAR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKAR→partner) and Y-score (partner→ANKAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.398	+2.115	<.001	<.001	3	4
UCEC	Notch1 →	+0.181	+1.836	<.001	.001	3	2
UCEC	PCNA →	+0.219	+2.662	.001	<.001	3	2
UCEC	Rab25 →	-0.266	-2.700	.010	.005	3	2
UCEC	Shc_pY317 →	-0.130	-1.353	.006	.015	3	2
UCEC	STAT3_pY705 →	-0.388	-1.836	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

p62 Lck ligand by ANKAR expression — UCEC

Explore this box plot interactively →