ANKAR

Across TCGA pan-cancer cohorts, ANKAR RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ANKAR’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ANKAR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ANKAR is over-expressed in tumor, although a few such as LUSC and BRCA show the opposite, repressed pattern.

KIRC, LIHC, and LUSC are the cancer types where ANKAR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANKAR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.474	<.001	11	view →
LIHC	Female	II,III,IV	+0.490	<.001	9	view →
LUSC	Male	III,IV	−0.697	.001	6	view →
BRCA	All	III,IV	−0.531	<.001	6	view →
UCEC	All	All	−0.514	<.001	6	view →
KICH	Female	All	−0.567	<.001	5	view →
THCA	All	All	−0.251	.002	4	view →
CHOL	All	All	+0.987	<.001	3	view →
COAD	All	All	+0.151	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ANKAR–KIRC

Open the KIRC breakdown →