ANKAR

Across TCGA cell cohorts, ANKAR mutation is significantly associated with the RNA expression of many other genes, with 443 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANKAR-associated genes across cancer lineages are PLA2G2E, OR2G3, and PNLIPRP3. Each is linked with ANKAR in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKAR-to-partner and partner-to-ANKAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLA2G2E grouped by ANKAR-low versus ANKAR-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKAR→partner) and Y-score (partner→ANKAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PLA2G2E →	+0.562	+4.817	<.001	.001	3	2
BLOOD_Leukemia	OR2G3 →	+0.049	+4.276	<.001	.007	3	1
BLOOD_Leukemia	PNLIPRP3 →	+0.010	+4.551	.001	.004	3	1
BLOOD_Leukemia	HTN3 →	+0.404	+4.551	<.001	.004	3	1
BLOOD_Leukemia	LRRC72 →	+0.022	+4.874	<.001	.002	3	1
BLOOD_Leukemia	C3orf85 →	+0.036	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 443 associations by consensus.

PLA2G2E by ANKAR expression — LUNG_SCLC

Explore this box plot interactively →