antagonist of mitotic exit network 1 homologGenealiases: []
Q-omics provides the consensus-scored AMN1 profile across patient tissues and cancer cell-line models. AMN1 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, AMN1 is differentially expressed in 10, with the highest sampling consensus in KIRC. Additionally, AMN1 RNA expression shows 20,126 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRP, KIRC, and UVM as cancer lineages where AMN1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for AMN1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes AMN1 survival associations across molecular data types. AMN1 RNA expression shows survival associations in the most cancer types (19), followed by mutation status (1) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible AMN1 RNA expression–survival associations across cancer types. High AMN1 expression shows unfavorable associations in KIRP, UVM and LIHC, but favorable associations in BRCA, SKCM and LGG. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .004). Together, the overview and detailed table identify KIRP as the clearest survival context for AMN1 RNA expression.
This table summarizes AMN1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for AMN1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. AMN1 shows lower tumor expression in KIRC, KICH and KIRP and higher tumor expression in LIHC, HNSC and CHOL. The KIRC box plot shows higher AMN1 RNA expression in normal versus tumor tissue (log2 FC = −0.562, t-test p < 0.001).
This table shows molecular features associated with AMN1 in patient tissues and cancer cell lines. In patient samples, AMN1 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, AMN1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in LIVER and BONE.
