AMN1

Across TCGA patient cohorts, AMN1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMN1-associated genes across cancer lineages are EGFR_pY1068, JNK2, and Notch1. Each is linked with AMN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMN1-to-partner and partner-to-AMN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by AMN1-low versus AMN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMN1→partner) and Y-score (partner→AMN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.303	-2.700	.007	.006	3	1
UCEC	JNK2 →	+0.233	+2.196	.009	.032	3	1
UCEC	Notch1 →	+0.134	+2.000	.034	.032	3	1
UCEC	Caspase-8 →	-0.251	-3.295	.026	.009	3	1
UCEC	Tuberin →	+0.345	+3.009	.004	.019	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

EGFR_pY1068 by AMN1 expression — UCEC

Explore this box plot interactively →