AMN1

Across TCGA cell cohorts, AMN1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible AMN1-associated genes across cancer lineages are VSIG4, HTR5A, and OR4S1. Each is linked with AMN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMN1-to-partner and partner-to-AMN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VSIG4 grouped by AMN1-low versus AMN1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMN1→partner) and Y-score (partner→AMN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	VSIG4 →	+0.036	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	HTR5A →	+0.006	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OR4S1 →	+0.063	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	CDY2A →	+0.126	+4.643	.001	.008	3	1
LUNG_NSCLC_LUSC	SRY →	+0.023	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OR5D18 →	+0.160	+4.643	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

VSIG4 by AMN1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →