AMN1

Across TCGA patient cohorts, AMN1 mutation is significantly associated with the RNA expression of many other genes, with 364 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMN1-associated genes across cancer lineages are RFKP1, PSMD14P1, and RN7SL392P. Each is linked with AMN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMN1-to-partner and partner-to-AMN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFKP1 grouped by AMN1-low versus AMN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMN1→partner) and Y-score (partner→AMN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RFKP1 →	+0.102	+2.541	<.001	.007	3	2
COAD	PSMD14P1 →	+0.296	+4.384	<.001	.006	3	2
UCEC	RN7SL392P →	+0.264	+2.719	<.001	.002	3	2
CESC	OR1L4 →	+0.057	+5.812	<.001	.003	3	1
CESC	RNA5-8SP5 →	+0.622	+6.342	<.001	.001	3	1
CESC	RNA5SP259 →	+0.360	+5.103	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 364 associations by consensus.

RFKP1 by AMN1 expression — UCEC

Explore this box plot interactively →