Q-omics provides the consensus-scored ALPK1 profile across patient tissues and cancer cell-line models. ALPK1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, ALPK1 is differentially expressed in 10, with the highest sampling consensus in KIRC. Additionally, ALPK1 RNA expression shows 20,214 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight SKCM, KIRC, and UVM as cancer lineages where ALPK1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ALPK1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ALPK1 survival associations across molecular data types. ALPK1 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (7) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ALPK1 RNA expression–survival associations across cancer types. High ALPK1 expression shows unfavorable associations in UVM, LGG, KIRC and KICH, but favorable associations in SKCM and BLCA. The SKCM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify SKCM as the clearest survival context for ALPK1 RNA expression.
This table summarizes ALPK1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for ALPK1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ALPK1 shows lower tumor expression in BRCA and KICH and higher tumor expression in KIRC, STAD, CHOL and KIRP. The KIRC box plot shows higher ALPK1 RNA expression in tumor versus normal tissue (log2 FC = +0.528, t-test p < 0.001).
This table shows molecular features associated with ALPK1 in patient tissues and cancer cell lines. In patient samples, ALPK1 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, ALPK1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in STOMACH and UPPER_AERODIGESTIVE_TRACT.
