ALPK1

Across TCGA cell cohorts, ALPK1 mutation is significantly associated with the RNA expression of many other genes, with 794 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALPK1-associated genes across cancer lineages are OR2L8, OR8B4, and DPH5. Each is linked with ALPK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALPK1-to-partner and partner-to-ALPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L8 grouped by ALPK1-low versus ALPK1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPK1→partner) and Y-score (partner→ALPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR2L8 →	+0.038	+4.450	<.001	.004	3	3
LUNG_NSCLC_LUAD	OR8B4 →	+0.034	+4.887	<.001	.009	3	2
SKIN	DPH5 →	+0.595	+3.628	<.001	<.001	3	2
SKIN	SET →	+0.527	+2.502	.005	.005	3	2
SKIN	TOM1L1 →	+0.548	+3.082	.002	.007	3	2
SKIN	CDC123 →	+0.535	+3.389	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 794 associations by consensus.

OR2L8 by ALPK1 expression — OVARY

Explore this box plot interactively →