ALPK1

Across TCGA patient cohorts, ALPK1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALPK1-associated genes across cancer lineages are 4E-BP1_pT37_T46, INPP4B, and Caveolin-1. Each is linked with ALPK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ALPK1-to-partner and partner-to-ALPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT37_T46 grouped by ALPK1-low versus ALPK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPK1→partner) and Y-score (partner→ALPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1_pT37_T46 →	-0.338	-1.912	.002	.004	3	4
LUAD	INPP4B →	-0.461	-3.000	.038	.035	3	3
LUAD	Caveolin-1 →	-0.847	-3.169	.025	.019	3	3
UCEC	Caspase-7-cleavedD198 →	+0.413	+1.604	.018	.010	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.335	-1.736	.011	.006	3	2
UCEC	PDCD4 →	-0.368	-1.058	.007	.037	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

4E-BP1_pT37_T46 by ALPK1 expression — UCEC

Explore this box plot interactively →