ALPK1

Across TCGA cell cohorts, ALPK1 mutation is significantly associated with the mutation status of many other genes, with 5,426 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALPK1-associated genes across cancer lineages are TOP2B, CPS1, and SCN4A. Each is linked with ALPK1 in more than 5 cancer types. Because this analysis shows association rather than direction, both ALPK1-to-partner and partner-to-ALPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOP2B grouped by ALPK1-low versus ALPK1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPK1→partner) and Y-score (partner→ALPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TOP2B →	+3.347	+2.870	.009	.009	1	6
BLOOD_Leukemia	CPS1 →	+3.347	+3.038	.002	.002	1	5
BLOOD_Leukemia	SCN4A →	+2.499	+2.697	.002	.002	1	5
OVARY	TTC21B →	+3.977	+4.930	.001	.001	1	5
OVARY	MTSS2 →	+4.977	+4.415	.007	.007	1	5
BLOOD_Leukemia	CACNA1B →	+3.932	+3.761	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,426 associations by consensus.

TOP2B by ALPK1 expression — BLOOD_Leukemia

Explore this box plot interactively →