aldehyde dehydrogenase 3 family member B1Genealiases: ALDH4 · ALDH7
Q-omics provides the consensus-scored ALDH3B1 profile across patient tissues and cancer cell-line models. ALDH3B1 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, ALDH3B1 is differentially expressed in 15, with the highest sampling consensus in KIRC. Additionally, ALDH3B1 protein abundance shows 31,137 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight ACC, KIRC, and GBM as cancer lineages where ALDH3B1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ALDH3B1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ALDH3B1 survival associations across molecular data types. ALDH3B1 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (2) and mass-spec protein abundance (12). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ALDH3B1 RNA expression–survival associations across cancer types. High ALDH3B1 expression shows unfavorable associations in PAAD, LGG and LUSC, but favorable associations in ACC, UVM and HNSC. The ACC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for ALDH3B1 RNA expression.
This table summarizes ALDH3B1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 12. The strongest signals are observed in KIRC for RNA and PDAC for protein.
This table ranks reproducible tumor–normal expression differences for ALDH3B1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ALDH3B1 shows lower tumor expression in LUSC and LUAD and higher tumor expression in KIRC, THCA, COAD and KIRP. The KIRC box plot shows higher ALDH3B1 RNA expression in tumor versus normal tissue (log2 FC = +1.666, t-test p < 0.001).
This table shows molecular features associated with ALDH3B1 in patient tissues and cancer cell lines. In patient samples, ALDH3B1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, ALDH3B1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BONE, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and OVARY.
