ALDH3B1

Across TCGA patient cohorts, ALDH3B1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH3B1-associated genes across cancer lineages are Notch1, IGFBP2, and p62 Lck ligand. Each is linked with ALDH3B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH3B1-to-partner and partner-to-ALDH3B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ALDH3B1-low versus ALDH3B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH3B1→partner) and Y-score (partner→ALDH3B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.140	+1.710	.008	.025	3	2
UCEC	IGFBP2 →	-0.662	-2.459	.006	.018	3	1
UCEC	p62 Lck ligand →	+0.402	+3.584	<.001	.002	3	1
UCEC	Annexin-1 →	+0.438	+2.479	.026	.010	3	1
UCEC	VHL →	-0.682	-1.906	.007	.015	3	1
UCEC	XBP1 →	-0.114	-1.415	.031	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Notch1 by ALDH3B1 expression — UCEC

Explore this box plot interactively →