ALDH3B1

Across TCGA pan-cancer cohorts, ALDH3B1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ALDH3B1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ALDH3B1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ALDH3B1 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

KIRC, THCA, and LUSC are the cancer types where ALDH3B1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ALDH3B1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.666	<.001	12	view →
THCA	Male	IV	+2.903	<.001	11	view →
LUSC	Female	II,III,IV	−3.731	<.001	9	view →
COAD	Male	II,III,IV	+0.765	<.001	9	view →
LUAD	Female	All	−1.720	<.001	8	view →
KIRP	All	All	+0.989	.001	7	view →
STAD	Male	All	+1.091	<.001	6	view →
HNSC	Male	IV	−0.976	.006	6	view →
CHOL	All	All	+2.510	<.001	5	view →
KICH	Female	All	−2.257	<.001	5	view →
LIHC	Female	All	+1.035	<.001	5	view →
BRCA	All	II,III,IV	+0.280	.008	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ALDH3B1–KIRC

Open the KIRC breakdown →