ALDH3B1

Across TCGA pan-cancer cohorts, ALDH3B1 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ALDH3B1’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where ALDH3B1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ALDH3B1 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

PDAC, LSCC, and LUAD are the cancer types where ALDH3B1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ALDH3B1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	All	+0.997	<.001	11	view →
LSCC	Male	All	−1.482	<.001	9	view →
LUAD	Female	III,IV	−1.475	<.001	9	view →
CCRCC	Male	II,III,IV	+0.383	<.001	7	view →
HNSC	Male	All	+0.226	.001	6	view →
COAD	Female	All	−0.491	.009	3	view →
OV	All	All	−0.710	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ALDH3B1–PDAC

Open the PDAC breakdown →