aldehyde dehydrogenase 1 family member A1Genealiases: ALDC · ALDH-E1 · ALDH1 · ALDH11 · HEL-9 · HEL-S-53e
Q-omics provides the consensus-scored ALDH1A1 profile across patient tissues and cancer cell-line models. ALDH1A1 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, ALDH1A1 is differentially expressed in 15, with the highest sampling consensus in KIRP. Additionally, ALDH1A1 protein abundance shows 24,064 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KIRC, KIRP, and GBM as cancer lineages where ALDH1A1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ALDH1A1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ALDH1A1 survival associations across molecular data types. ALDH1A1 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (7) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ALDH1A1 RNA expression–survival associations across cancer types. High ALDH1A1 expression shows unfavorable associations in UCS, but favorable associations in KIRC, BRCA, SARC, MESO and HNSC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for ALDH1A1 RNA expression.
This table summarizes ALDH1A1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 7. The strongest signals are observed in KIRP for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for ALDH1A1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ALDH1A1 shows lower tumor expression in THCA, KICH, COAD, HNSC and LUAD and higher tumor expression in KIRP. The KIRP box plot shows higher ALDH1A1 RNA expression in tumor versus normal tissue (log2 FC = +1.810, t-test p < 0.001).
This table shows molecular features associated with ALDH1A1 in patient tissues and cancer cell lines. In patient samples, ALDH1A1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, ALDH1A1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BONE, while CRISPR and shRNA rows add functional-dependency signals in OVARY and BLOOD_Leukemia.
