ALDH1A1

Across TCGA cell cohorts, ALDH1A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,941 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALDH1A1-associated GO terms across cancer lineages are 9-cis-retinoic acid biosynthetic process, 9-cis-retinoic acid metabolic process, and Retinoic acid biosynthetic process. Each is linked with ALDH1A1 in more than 12 cancer types. Because this analysis shows association rather than direction, both ALDH1A1-to-partner and partner-to-ALDH1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 9-cis-retinoic acid biosynthetic process grouped by ALDH1A1-low versus ALDH1A1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH1A1→partner) and Y-score (partner→ALDH1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	9-cis-retinoic acid biosynthetic process →	+1.911	+6.227	<.001	<.001	3	13
LUNG_SCLC	9-cis-retinoic acid metabolic process →	+1.911	+6.227	<.001	<.001	3	13
BONE	Retinoic acid biosynthetic process →	+1.445	+3.649	<.001	<.001	3	13
LIVER	GABA metabolic process →	+0.300	+6.204	<.001	<.001	3	12
LIVER	GABA biosynthetic process →	+0.379	+5.625	<.001	.002	3	12
LUNG_NSCLC_LUSC	Non-proteinogenic amino acid biosynthetic process →	+0.310	+5.982	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,941 associations by consensus.

9-cis-retinoic acid biosynthetic process by ALDH1A1 expression — LUNG_SCLC

Explore this box plot interactively →