ALDH1A1

Across TCGA patient cohorts, ALDH1A1 mutation is significantly associated with the RNA expression of many other genes, with 422 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH1A1-associated genes across cancer lineages are FAM230D, ATP5MFP1, and OBSCN-AS1. Each is linked with ALDH1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH1A1-to-partner and partner-to-ALDH1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM230D grouped by ALDH1A1-low versus ALDH1A1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH1A1→partner) and Y-score (partner→ALDH1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	FAM230D →	+0.018	+3.413	.004	.001	3	2
LUAD	ATP5MFP1 →	+0.408	+4.481	<.001	.005	3	2
UCEC	OBSCN-AS1 →	-0.584	-2.415	.003	.003	3	2
UCEC	EOMES →	+0.422	+2.831	.009	.001	3	2
UCEC	ERMAP →	-0.577	-2.415	<.001	.003	3	2
UCEC	CD3D →	+1.029	+3.601	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 422 associations by consensus.

FAM230D by ALDH1A1 expression — BLCA

Explore this box plot interactively →