ALDH1A1

Across TCGA pan-cancer cohorts, ALDH1A1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ALDH1A1 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ALDH1A1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ALDH1A1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, UCEC, and HNSC are the cancer types where ALDH1A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.501	0.246	<.001	106	view →
UCEC	OS	Median	II,III,IV	0.590	1.000	.007	44	view →
HNSC	DFS	Median	II,III,IV	0.896	0.975	.030	4	view →
GBM	OS	Tertile	All	0.444	0.647	.036	4	view →
LUAD	DFS	Quartile	All	0.789	0.527	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ALDH1A1–PDAC (DFS)

Open the PDAC breakdown →