ALDH1A1

Across TCGA pan-cancer cohorts, ALDH1A1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ALDH1A1 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher ALDH1A1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ALDH1A1 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

ESCA, LUAD, and BLCA are the cancer types where ALDH1A1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	II,III,IV	0.209	0.531	.007	27	view →
LUAD	OS	Median	II,III,IV	0.147	0.709	<.001	24	view →
BLCA	DFS	Median	II,III,IV	0.892	0.321	.012	14	view →
OV	OS	Median	IV	0.007	0.760	<.001	12	view →
COAD	OS	Median	III,IV	0.159	0.692	.021	9	view →
LIHC	OS	Median	All	0.144	0.688	.013	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ALDH1A1–ESCA (DFS)

Open the ESCA breakdown →