ALDH1A1

Across TCGA cell cohorts, ALDH1A1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALDH1A1-associated genes across cancer lineages are MYF6, GKN1, and OR1L6. Each is linked with ALDH1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH1A1-to-partner and partner-to-ALDH1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYF6 grouped by ALDH1A1-low versus ALDH1A1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH1A1→partner) and Y-score (partner→ALDH1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MYF6 →	+0.014	+4.415	<.001	.007	3	1
LARGE_INTESTINE	GKN1 →	+0.045	+4.095	.002	.009	3	1
LARGE_INTESTINE	OR1L6 →	+0.027	+5.022	<.001	.002	3	1
LARGE_INTESTINE	SLC15A5 →	+0.017	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MYF6 by ALDH1A1 expression — LARGE_INTESTINE

Explore this box plot interactively →