ALDH1A1

Across TCGA patient cohorts, ALDH1A1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH1A1-associated genes across cancer lineages are TFRC, eIF4E, and Fibronectin. Each is linked with ALDH1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH1A1-to-partner and partner-to-ALDH1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by ALDH1A1-low versus ALDH1A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH1A1→partner) and Y-score (partner→ALDH1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.730	+3.169	.001	.018	3	2
UCEC	eIF4E →	+0.198	+3.584	.027	.002	3	1
UCEC	Fibronectin →	-0.297	-3.156	.033	.018	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.491	+2.222	.023	.011	3	1
UCEC	JNK2 →	+0.259	+2.222	.002	.011	3	1
UCEC	Ku80 →	+0.230	+1.713	.021	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

TFRC by ALDH1A1 expression — UCEC

Explore this box plot interactively →