actin related protein T1Genealiases: AIP1 · ARIP1 · ARPT1 · HSD27
Q-omics provides the consensus-scored ACTRT1 profile across patient tissues and cancer cell-line models. ACTRT1 expression is associated with patient survival in 13 of 34 cancer types, with the highest sampling consensus in LIHC. Among the 18 cancer types available for tumor–normal comparison, ACTRT1 is differentially expressed in 2, with the highest sampling consensus in STAD. Additionally, ACTRT1 protein abundance shows 27,589 significant protein co-abundance associations, with the highest sampling consensus in LUAD. Together, these results highlight LIHC, STAD, and LUAD as cancer lineages where ACTRT1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ACTRT1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ACTRT1 survival associations across molecular data types. ACTRT1 RNA expression shows survival associations in the most cancer types (13), followed by mutation status (7) and mass-spec protein abundance (10). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ACTRT1 RNA expression–survival associations across cancer types. High ACTRT1 expression shows unfavorable associations in LIHC, STAD, ESCA, READ and CHOL, but favorable associations in THYM. The LIHC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LIHC as the clearest survival context for ACTRT1 RNA expression.
This table summarizes ACTRT1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2, while mass-spec protein shows differences in 9. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for ACTRT1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ACTRT1 shows higher tumor expression in STAD and KIRC. The STAD box plot shows higher ACTRT1 RNA expression in tumor versus normal tissue (log2 FC = +0.025, t-test p = .026).
This table shows molecular features associated with ACTRT1 in patient tissues and cancer cell lines. In patient samples, ACTRT1 shows the broadest associations at the RNA and protein expression levels, with LUAD recurring as the lineage with the largest associated feature set. In cancer cell lines, ACTRT1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and OVARY.
