ACTRT1

Across TCGA patient cohorts, ACTRT1 mutation is significantly associated with the RNA expression of many other genes, with 4,284 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTRT1-associated genes across cancer lineages are RNU6-1174P, SSRP1, and CHEK1. Each is linked with ACTRT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTRT1-to-partner and partner-to-ACTRT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1174P grouped by ACTRT1-low versus ACTRT1-high in ESCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTRT1→partner) and Y-score (partner→ACTRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	RNU6-1174P →	+0.863	+4.159	<.001	.009	3	3
UCEC	SSRP1 →	+0.451	+2.280	.002	<.001	3	3
UCEC	CHEK1 →	+0.720	+3.108	<.001	<.001	3	3
UCEC	SEC13 →	+0.308	+1.836	.002	.001	3	3
UCEC	C1orf50 →	+0.307	+2.158	<.001	<.001	3	3
UCEC	WRN →	+0.425	+2.264	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,284 associations by consensus.

RNU6-1174P by ACTRT1 expression — ESCA

Explore this box plot interactively →