ACTRT1

Across TCGA cell cohorts, ACTRT1 mutation is significantly associated with the mutation status of many other genes, with 1,324 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible ACTRT1-associated genes across cancer lineages are NPHP4, PPL, and NCKAP1. Each is linked with ACTRT1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ACTRT1-to-partner and partner-to-ACTRT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPHP4 grouped by ACTRT1-low versus ACTRT1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTRT1→partner) and Y-score (partner→ACTRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NPHP4 →	+3.784	+3.115	.001	.001	1	4
BONE	PPL →	+5.437	+5.437	.003	.003	1	3
BONE	NCKAP1 →	+5.437	+5.437	.003	.003	1	3
LUNG_NSCLC_LUAD	OLFM1 →	+3.718	+3.718	.003	.003	1	3
OVARY	PXDN →	+2.514	+2.925	.007	.007	1	3
OVARY	ANKHD1 →	+3.099	+3.832	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,324 associations by consensus.

NPHP4 by ACTRT1 expression — LUNG_SCLC

Explore this box plot interactively →