ACTRT1

Across TCGA patient cohorts, ACTRT1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTRT1-associated genes across cancer lineages are Cyclin-B1, Dvl3, and VHL. Each is linked with ACTRT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTRT1-to-partner and partner-to-ACTRT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ACTRT1-low versus ACTRT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTRT1→partner) and Y-score (partner→ACTRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.666	+3.807	<.001	<.001	3	3
LUAD	Dvl3 →	+0.186	+2.239	.003	.005	3	2
LUSC	VHL →	-0.881	-3.321	.014	.009	3	2
LUSC	Chk1 →	+0.179	+3.000	.038	.035	3	2
UCEC	FoxM1 →	+0.221	+2.459	.013	<.001	3	2
UCEC	IRS1 →	+0.195	+1.700	.006	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Cyclin-B1 by ACTRT1 expression — UCEC

Explore this box plot interactively →