actin related protein 8Genealiases: ARP8 · INO80N · hArp8
Q-omics provides the consensus-scored ACTR8 profile across patient tissues and cancer cell-line models. ACTR8 expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, ACTR8 is differentially expressed in 10, with the highest sampling consensus in LIHC. Additionally, ACTR8 protein abundance shows 27,119 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight ACC, LIHC, and LSCC as cancer lineages where ACTR8 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ACTR8 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ACTR8 survival associations across molecular data types. ACTR8 RNA expression shows survival associations in the most cancer types (27), followed by mutation status (3) and mass-spec protein abundance (10). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ACTR8 RNA expression–survival associations across cancer types. High ACTR8 expression shows unfavorable associations in ACC, LUSC and LIHC, but favorable associations in KIRC, KIRP and BRCA. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for ACTR8 RNA expression.
This table summarizes ACTR8 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 10. The strongest signals are observed in LIHC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for ACTR8. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ACTR8 shows lower tumor expression in KIRC and KICH and higher tumor expression in LIHC, COAD, STAD and CHOL. The LIHC box plot shows higher ACTR8 RNA expression in tumor versus normal tissue (log2 FC = +1.074, t-test p < 0.001).
This table shows molecular features associated with ACTR8 in patient tissues and cancer cell lines. In patient samples, ACTR8 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, ACTR8 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in KIDNEY, while CRISPR and shRNA rows add functional-dependency signals in PANCREAS and BLOOD_Leukemia.
