ACTR8

Across TCGA patient cohorts, ACTR8 mutation is significantly associated with the RNA expression of many other genes, with 1,277 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTR8-associated genes across cancer lineages are RNA5SP396, TMEM225, and TRDD1. Each is linked with ACTR8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTR8-to-partner and partner-to-ACTR8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP396 grouped by ACTR8-low versus ACTR8-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTR8→partner) and Y-score (partner→ACTR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP396 →	+0.189	+4.455	<.001	.005	3	3
READ	TMEM225 →	+0.114	+5.039	<.001	.008	3	2
BRCA	TRDD1 →	+1.367	+9.057	<.001	.003	3	2
UCEC	ESS2 →	+0.362	+4.010	<.001	<.001	3	2
UCEC	GGA1 →	+0.394	+2.928	.001	.001	3	2
UCEC	POP7 →	+0.382	+3.374	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,277 associations by consensus.

RNA5SP396 by ACTR8 expression — BLCA

Explore this box plot interactively →