ACTR8

Across TCGA pan-cancer cohorts, ACTR8 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ACTR8 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ACTR8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ACTR8 expression acts as an unfavorable survival marker, although some lineages such as KIRC and KIRP show a favorable association.

ACC, KIRC, and KIRP are the cancer types where ACTR8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.254	0.622	<.001	89	view →
KIRC	DFS	Tertile	All	0.722	0.528	<.001	77	view →
KIRP	OS	Tertile	All	0.898	0.634	.001	64	view →
BRCA	OS	Tertile	III,IV	0.946	0.757	<.001	63	view →
LUSC	DFS	Median	III,IV	0.522	0.793	.001	57	view →
LIHC	DFS	Tertile	All	0.427	0.607	<.001	56	view →
KICH	DFS	Tertile	II,III,IV	0.523	0.950	.004	51	view →
READ	OS	Median	All	0.969	0.301	<.001	51	view →
COAD	OS	Tertile	IV	0.782	0.363	<.001	40	view →
MESO	OS	Median	III,IV	0.462	0.659	.002	32	view →
SCLC	OS	Quartile	All	0.559	0.249	.001	24	view →
GBM	DFS	Tertile	All	0.416	0.183	.004	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ACTR8–ACC (DFS)

Open the ACC breakdown →