ACTR8

Across TCGA patient cohorts, ACTR8 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTR8-associated genes across cancer lineages are EGFR_pY1068, ACC_pS79, and GATA6. Each is linked with ACTR8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTR8-to-partner and partner-to-ACTR8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ACTR8-low versus ACTR8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTR8→partner) and Y-score (partner→ACTR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.355	-2.700	.001	.006	3	1
UCEC	ACC_pS79 →	+0.465	+2.999	.002	.035	3	1
UCEC	GATA6 →	-0.184	-2.985	.010	.034	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.387	+2.331	.044	.019	3	1
UCEC	ACC1 →	+0.446	+3.183	.006	.009	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.532	+3.009	.020	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

EGFR_pY1068 by ACTR8 expression — UCEC

Explore this box plot interactively →