GO:0035249Ontology (GO BP)GO biological process · ~110 member genes
Q-omics provides the "Synaptic transmission, glutamatergic" (GO:0035249) pathway profile, scoring each patient from the combined activity of its roughly 110 member genes. Pathway activity is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, the pathway is differentially active in 13, with the highest sampling consensus in KIRC. Additionally, pathway RNA activity shows 29,662 significant cross-omics associations, again with the highest sampling consensus in LGG. Together, these results highlight HNSC, KIRC, and LGG as cancer lineages where the pathway shows reproducible signals across outcome, tissue activity, and molecular association analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns. Pathway-against-pathway and pathway-against-mutation comparisons are not available for ontology entities.
Survival associations
This table summarizes "Synaptic transmission, glutamatergic" survival associations by molecular data type. RNA-level pathway activity shows survival associations in the most cancer types (27). The rightmost column indicates the cancer type with the highest sampling consensus for each layer.
This table ranks reproducible pathway activity–survival associations across cancer types. High "Synaptic transmission, glutamatergic" activity shows favorable associations in KIRP, LGG, UVM and ACC, but unfavorable associations in HNSC and BLCA. In the HNSC Kaplan–Meier curve the high-activity group declines faster, consistent with the unfavorable association (log-rank p = .001). HNSC ranks highest by sampling consensus for "Synaptic transmission, glutamatergic".
This table summarizes "Synaptic transmission, glutamatergic" tumor–normal activity differences by data type. RNA-level activity shows significant tumor–normal differences in 13 cancer types, while mass-spec protein activity shows differences in 6. The strongest signals are in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal activity differences for the pathway. A positive fold-change indicates higher activity in tumor tissue. The pathway shows higher tumor activity across KIRC, KIRP, HNSC, KICH and COAD and lower tumor activity in LUSC. In the KIRC box plot, tumor samples show higher pathway activity than matched normal samples (log2 FC = +0.042, t-test p < 0.001).
This table shows molecular features associated with "Synaptic transmission, glutamatergic" pathway activity in patient tissues and cancer cell lines. In patient samples, pathway activity is most strongly linked to RNA and protein features, with the largest associated set in LGG. In cancer cell lines, RNA-expression features and functional dependencies dominate, with the largest set in UPPER_AERODIGESTIVE_TRACT.
