"Synaptic transmission, glutamatergic"

Across TCGA patient cohorts, RNA activity of the "Synaptic transmission, glutamatergic" pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPRD2, ASAP1_S1008, and RIPK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Synaptic transmission, glutamatergic" activity versus RPRD2 in HNSC (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPRD2 →	-0.271	-0.039	<.001	<.001	3	5
LSCC	ASAP1_S1008 →	+0.490	+0.028	.001	.005	3	5
LSCC	RIPK2 →	+0.272	+0.033	<.001	.001	3	5
GBM	SON →	-0.168	-0.044	.003	.001	3	5
LUAD	F11R →	-0.334	-0.033	.001	<.001	3	5
CCRCC	LTBP4 →	-0.546	-0.033	.007	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035249 vs RPRD2 — HNSC

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