"Synaptic transmission, glutamatergic"

Across TCGA pan-cancer cohorts, RNA activity of the "Synaptic transmission, glutamatergic" pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 110 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher "Synaptic transmission, glutamatergic" pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and LGG, show the opposite pattern, with higher activity associated with better survival.

HNSC, BLCA, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.600	0.732	.001	71	view →
BLCA	DFS	Median	All	0.322	0.591	<.001	70	view →
KIRP	DFS	Median	III,IV	0.642	0.145	.002	55	view →
LGG	DFS	Median	All	0.799	0.675	<.001	51	view →
UVM	DFS	Tertile	II,III,IV	0.761	0.380	.001	43	view →
ACC	DFS	Median	III,IV	0.844	0.298	.011	36	view →
SKCM	DFS	Tertile	III,IV	0.448	0.867	<.001	31	view →
ESCA	OS	Median	II,III,IV	0.324	0.583	.001	25	view →
CESC	OS	Median	All	0.820	0.908	.009	18	view →
LUSC	OS	Median	II,III,IV	0.684	0.792	.010	16	view →
SCLC	DFS	Quartile	All	0.251	0.574	.014	16	view →
CHOL	DFS	Tertile	III,IV	0.162	0.779	.024	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0035249–HNSC (DFS)

Open the HNSC breakdown →