"Synaptic transmission, glutamatergic"

Across TCGA cell cohorts, RNA activity of the "Synaptic transmission, glutamatergic" pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC1A4, ZNF526, and PRRT3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Synaptic transmission, glutamatergic" activity versus SLC1A4 in BONE (Pearson r = 0.96).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SLC1A4 →	+2.863	+0.634	.003	.007	2	5
CNS	ZNF526 →	+0.671	+0.249	.007	.001	3	3
SKIN	PRRT3 →	-0.654	-0.309	.001	.002	3	3
LUNG_NSCLC_LUSC	CNOT10 →	-0.566	-1.526	.002	<.001	3	3
SOFT_TISSUE	RAP2A →	+1.015	+0.243	.002	.007	3	3
KIDNEY	AP1S2 →	+1.863	+0.194	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035249 vs SLC1A4 — BONE

Explore this scatter interactively →