"Synaptic transmission, glutamatergic"

Across TCGA patient cohorts, RNA activity of the "Synaptic transmission, glutamatergic" pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STEAP4, ZWINT, and CKS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Synaptic transmission, glutamatergic" activity versus STEAP4 in BRCA (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	STEAP4 →	+1.181	+0.240	<.001	.001	3	5
LSCC	ZWINT →	-0.861	-0.624	<.001	.008	3	5
OV	CKS2 →	-0.587	-0.332	.001	.004	3	5
BRCA	CENPW →	-0.933	-0.181	<.001	.003	3	5
LSCC	FEN1 →	-0.782	-0.798	<.001	<.001	3	5
LSCC	SAC3D1 →	-0.501	-0.665	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035249 vs STEAP4 — BRCA

Explore this scatter interactively →