"Synaptic transmission, glutamatergic"

Across TCGA cell cohorts, RNA activity of the "Synaptic transmission, glutamatergic" pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX6B1, XRCC4, and ZFHX3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COX6B1 grouped by "Synaptic transmission, glutamatergic"-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	COX6B1 →	-0.626	-0.196	.007	.003	2	4
BREAST	XRCC4 →	-0.631	-0.894	.009	.008	3	3
SKIN	ZFHX3 →	-0.612	-1.083	.004	.008	2	4
LARGE_INTESTINE	PANX1 →	-0.740	-0.913	.006	.002	3	3
LARGE_INTESTINE	SDF2 →	-0.437	-1.199	.006	<.001	3	3
LARGE_INTESTINE	NKIRAS2 →	-0.435	-0.776	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COX6B1 by "Synaptic transmission, glutamatergic" activity — OESOPHAGUS

Explore this box plot interactively →