"Synaptic transmission, glutamatergic"

Across TCGA patient cohorts, RNA activity of the "Synaptic transmission, glutamatergic" pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D10C, TCP11L1, and S1PR4, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Synaptic transmission, glutamatergic" activity versus TBC1D10C in THYM (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	TBC1D10C →	-1.866	-0.029	<.001	<.001	3	17
TGCT	TCP11L1 →	+0.603	+0.018	<.001	<.001	3	17
THYM	S1PR4 →	-1.601	-0.025	<.001	<.001	3	16
SCLC	LTB →	-1.836	-0.069	<.001	<.001	3	16
SCLC	WDR47 →	+2.158	+0.055	<.001	.006	3	16
ESCA	ACKR1 →	-1.415	-0.020	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035249 vs TBC1D10C — THYM

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