Q-omics provides the consensus-scored ZNF335 profile across patient tissues and cancer cell-line models. ZNF335 expression is associated with patient survival in 29 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, ZNF335 is differentially expressed in 15, with the highest sampling consensus in HNSC. Additionally, ZNF335 RNA expression shows 20,556 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRP, HNSC, and ACC as cancer lineages where ZNF335 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ZNF335 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ZNF335 survival associations across molecular data types. ZNF335 RNA expression shows survival associations in the most cancer types (29), followed by mutation status (6) and mass-spec protein abundance (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ZNF335 RNA expression–survival associations across cancer types. High ZNF335 expression shows unfavorable associations in KIRP, ACC, KIRC, LIHC and UVM, but favorable associations in HNSC. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for ZNF335 RNA expression.
This table summarizes ZNF335 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for ZNF335. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ZNF335 shows higher tumor expression in HNSC, KIRC, COAD, LIHC, STAD and KIRP. The HNSC box plot shows higher ZNF335 RNA expression in tumor versus normal tissue (log2 FC = +0.854, t-test p < 0.001).
This table shows molecular features associated with ZNF335 in patient tissues and cancer cell lines. In patient samples, ZNF335 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, ZNF335 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BONE, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and LARGE_INTESTINE.
