Across TCGA patient cohorts, ZNF335 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF335-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and c-Kit. Each is linked with ZNF335 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF335-to-partner and partner-to-ZNF335 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF335→partner) and Y-score (partner→ZNF335) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.454	-1.807	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.604	+1.378	<.001	.008	3	3
STAD	c-Kit →	-0.332	-3.000	.043	.036	3	2
SKCM	PRAS40_pT246 →	+0.174	+2.000	.013	.031	3	2
SKCM	Tuberin_pT1462 →	+0.359	+3.169	.004	.017	3	2
UCEC	eEF2 →	+0.235	+2.222	.028	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Exploration

ZNF335 survival (RNA) · tumor vs normal (RNA) · all ZNF335 data types