Q-omics provides the consensus-scored WDR38 profile across patient tissues and cancer cell-line models. WDR38 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, WDR38 is differentially expressed in 11, with the highest sampling consensus in THCA. Additionally, WDR38 RNA expression shows 11,464 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight KICH, THCA, and TGCT as cancer lineages where WDR38 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for WDR38 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes WDR38 survival associations across molecular data types. WDR38 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible WDR38 RNA expression–survival associations across cancer types. High WDR38 expression shows unfavorable associations in KICH, LGG, LIHC and ACC, but favorable associations in HNSC and BRCA. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KICH as the clearest survival context for WDR38 RNA expression.
This table summarizes WDR38 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for WDR38. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. WDR38 shows lower tumor expression in THCA, KICH, LUSC and LUAD and higher tumor expression in KIRC and STAD. The THCA box plot shows higher WDR38 RNA expression in normal versus tumor tissue (log2 FC = −0.759, t-test p < 0.001).
This table shows molecular features associated with WDR38 in patient tissues and cancer cell lines. In patient samples, WDR38 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, WDR38 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in SKIN and SOFT_TISSUE.
