WDR38

Across TCGA patient cohorts, WDR38 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR38-associated genes across cancer lineages are PRDX1, VHL, and Bax. Each is linked with WDR38 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR38-to-partner and partner-to-WDR38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by WDR38-low versus WDR38-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR38→partner) and Y-score (partner→WDR38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRDX1 →	+0.195	+2.321	.035	.034	3	2
UCEC	VHL →	-1.142	-2.459	<.001	.019	3	2
UCEC	Bax →	+0.287	+2.000	.007	.032	3	2
UCEC	eEF2 →	+0.529	+2.700	<.001	.006	3	1
UCEC	ERK2 →	+0.281	+3.459	.001	.005	3	1
UCEC	ETS-1 →	+0.309	+2.000	.031	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

PRDX1 by WDR38 expression — UCEC

Explore this box plot interactively →